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Linda J. Pike
Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research Interests
Mechanism of action of growth factors;
polyphosphoinositide
metabolism
Selected Publications
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Macdonald-Obermann, J.L. and Pike, L.J. The intracellular juxtamembrane domain of the EGF receptor is responsible for the allosteric regulation of EGF binding. J Biol Chem 284:13570-13576 (2009).
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Macdonald-Obermann, J.L. and Pike, L.J. Palmitoylation of the EGF receptor impairs signal transduction and abolishes
high-affinity ligand binding. Biochemistry 48:2505-2513 (2009).
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Yang, K.S., Ilagan, MX., Pinica-Worms, D. and Pike, L.J. Luciferase fragment complementation imaging of conformational changes in the EGF receptor. J Biol Chem 284:7474-7482 (2009)
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Pike, L.J. The challenge of lipid rafts. J. Lipid Res. 50:S323-S328 (2009).
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Eiblmaier, M., Meyer, L.A., Watson, M.A., Fracasso, P.M., Pike, L.J. and Anderson, C.J. Correlating EGFR expression with receptor-binding properties and internalization of 64Cu-DOTA-Cetuximab in 5 cervical cancer cell lines. J Nucl Med 49:1472-1479 (2008).
