PUBLICATIONS

2009 | 2008 | 2007 | 2006 | 2005 | 2004

The following is a partial list of publications by faculty, post-doctoral fellows, students, and staff of Molecular Biophysics and Biochemistry arranged by labs.

Nathan A. Baker

Dong, F., Wagoner, J.A. and Baker, N.A. Assessing the performance of implicit solvation models at a nucleic acid surface. Phys. Chem. Chem. Phys. 10:4889-4902, (2008).
Bradley, M.J., Chivers, P.T. and Baker, N.A. Molecular dynamics simulation of the Escherichia coli NikR protein: Equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. J Mol Biol. 378:1155-1173 (2008).
Lee, S.J., Song, Y. and Baker, N.A. Molecular dynamics simulations of asymmetric NaCl and KCl solutions separated by phosphatidylcholine bilayers: Potential drops and structural changes induced by strong Na+-lipid interactions and finite size effects. Biophys J. 94:3565-3576 (2008).
Dong, F., Olsen, B. and Baker, N.A. Computational methods for biomolecular electrostatics. Methods Cell Biol. 84:843-870 (2008).

Peter M. Burgers

Stith, C.M., Sterling, J., Resnick, M.A., Gordenin, D.A. and Burgers, P.M. Flexibility of eukaryotic okazaki fragment maturation through regulated strand sisplacement synthesis. J Biol Chem. 283:34129-40 (2008).
Navadgi-Patil, V.M. and Burgers, P.M. Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem 283:35853-35859 (2008).
Kunkel, T.A. and Burgers, P.M. Dividing the workload at a eukaryotic replication fork. Trends Cell Biol 18:521-527 (2008).
Rossi, M.L., Pike, J.E., Wang, W., Burgers, P.M., Campbell, J.L. and Bambara, R.A. Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem 283:27483-27493 (2008).
Sommer, D., Stith, C.M., Burgers, P.M.J. and Lahue, R.S. Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae. Nuc Acid Res 6:4699-4707 (2008).
Nick McElhinny, S.A., Gordenin, D.A., Stith, C.M., Burgers, P.M. and Kunkel, T.A. Division of labor at the eukaryotic replication fork. Mol Cell. 30:137-144 (2008).
Wardle, J., Burgers, P.M., Cann, I.K., Darley, K., Darley, K., Heslop, P., Johansson, E., Lin, L.J., McGlynn, P., Sanvoisin, J., Stith, C.M. and Connolly, B.A. Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya. Nucleic Acids Res 36:705-711 (2008).

Peter T. Chivers

Iwig, J.S., Leitch, S., Herbst, R.W., Maroney, M.J. and Chivers, P.T. Ni(II) and Co(II) sensing by Escherichia coli RcnR. J Am Chem Soc. 130:7592-7606 (2008).
Bradley, M.J., Chivers, P.T. and Baker, N.A. Molecular dynamics simulation of the Escherichia coli NikR protein: Equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. J Mol Biol. 378:1155-1173 (2008).

Enrico Di Cera

Papaconstantinou, M.E., Gandhi, P.S., Chen, Z., Bah, A. and Di Cera, E. Na(+) Binding to meizothrombin desF1. Cell Mol Life Sci. 65:3688-3697 (2008).
Page, M.J. and Di Cera, E. Evolution of peptidase diversity. J Biol Chem 283:30010-30014 (2008).
Di Cera, E. How I became a biochemist. IUBMB Life 60:859-861 (2008).
Tanaka, K.A., Gruber, A., Szlam, F., Bush, L.A., Hanson, S.R. and Di Cera, E. Interaction between thrombin mutant W215A/E217A and direct thrombin I\inhibitor. Blood Coagul Fibrinolysis 19:465-468 (2008).
Papaconstantinou, M.E., Bah, A. and Di Cera, E. Role of the A chain in thrombin function. Cell Mol Life Sci. 65:1943-1947 (2008)
Di Cera, E. Engineering protease specificity made simple, but not simpler. Nat Chem Biol 4:270-271 (2008).
Page, M.J., Carrell, C.J. and Di Cera, E. Engineering protein allostery: 1.05 A resolution structure and enzymatic properties of a Na(+)-activated trypsin. J Mol Biol. 378:666-672. (2008).
Di Cera, E. Thrombin. Mol Aspects Med. 29:203-254 (2008).
Nieman, M.T., Burke, F., Warnock, M., Zhou, Y., Sweigart, J., Chen, A., Ricketts, D., Lucchesi, B.R., Chen, Z., Di Cera, E., Hilfinger, J., Kim, J.S., Mosberg, H.I. and Schmaier, A.H. Thrombostatin FM compounds: Direct thrombin inhibitors - Mechanism of action in vitro and in vivo. J Thromb Haemost. 6:837-845 (2008).
Page, M.J. and Di Cera, E. Serine peptidases: Classification, structure and function. Cell Mol Life Sci. 65:1220-1236 (2008).
Gandhi, P.S., Chen, Z., Mathews, F.S. and Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 105:1832-1837 (2008).
Berny, M.A., White, T.C., Tucker, E.I., Bush-Pelc, L.A., Di Cera, E., Gruber, A. and McCarty, O.J. Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol. 28:329-334 (2008).

Tom Ellenberger

Raschle, M., Knipsheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D. and Walter, J.C. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134:969-980. (2008).
Zhong, S., Chen, X., Zhu, X., Dziegielewska, B., Bachman, K.E., Ellenberger, T., Ballin, J.D., Wilson, G.M., Tomkinson, A.E. and MacKerell, Jr., A.D. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem 51:4553-4562 (2008).
Ellenberger, T. and Tomkinson, A.E. Eukaryotic DNA ligases: Structural and functional insights. Annu Rev Biochem 77:313-338 (2008).
Chen, X., Zhong, S., Zhu, X., Dziegielewska, B., Ellenberger, T., Wilson, G.M., MacKerell, A.D. Jr and Tomkinson, A.E. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68:3169-3177 (2008).
Cotner-Gohara, E., Kim, I.K., Tomkinson, A.E. and Ellenberger, T. Two DNA binding and nick recognition modules in human DNA ligase III. J. Biol. Chem. 283:10764-10772 (2008).

Elliot Elson

Nekouzadeh, A., Pryse, K.M., Elson, E.L. and Genin, G.M. Stretch-activated force shedding, force recovery, and cytoskeletal remodeling in contractile fibroblasts. J Biomech. 41:2964-2971 (2008).
Tan, Y.C., Shen, A.Q., Li, Y., Elson, E. and Ma, L. Engineering lipid tubules using nano-sized building blocks: The combinatorial self-assembly of vesicles. Lab on a Chip 8:339-345 (2008).

William A. Frazier

Isenberg, J.S. Maxhimer, J.B., Powers, P., Tsokos, M., Frazier, W.A. and Robert, D.D. Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling. Surgery 144:752-761 (2008).
Isenberg, J.S., Frazier, W.A., Krishna, M.C., Wink, D.A. and Roberts, D.D. Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. Curr Drug Targets 9:833-841 (2008).
Vomund, A.N., Stuhlsatz-Krouper, S., Dimitry, J., Song, Y. and Frazier, W.A. A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 Integrins in a bent, resting conformation. Biochemistry 47:11616-11624 (2008).
Isenberg, J.S., Romeo, M.J., Maxhimer, J.B., Smedley, J., Frazier, W.A. and Roberts, D.D. Gene silencing of CD47 and antibody ligation of Thrombospondin-1 enhance ischemic tissue survival in a porcine model: Implications for human disease. Ann Surg. 247:860-868 (2008).
Isenberg, J.S., Romeo, M.J, Yu, C., Yu, C.K., Nghiem, K., Monsale, J., Rick, M.E., Wink, D.A., Frazier, W.A. and Roberts, D.D. Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood 111:613-623 (2008).
Isenberg, J.S., Roberts, D.D. and Frazier, W.A. CD47. A new target in cardiovascular therapy. Arterioscler Thromb Vasc Biol. 28:615-621 (2008).
Isenberg, J.S., Pappan, L.K., Romeo, M.J., Abu-Asab, M., Tsokos, M., Wink, D.A., Frazier, W.A. and Roberts, D.D. Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. Ann Surg. 247:180-190 (2008).

Carl Frieden

Frieden, C. A lifetime of kinetics. J Biol Chem. 283:19873-19878 (2008).

Kathleen Hall

Hall, K.B. RNA in motion. Curr Opin Chem Biol 12:612-618 (2008).

Katherine Henzler-Wildman

Porcelli, F., Verardi, R., Shi, L., Henzler-Wildman, K.A., Ramamoorthy, A., and Veglia, G. NMR Structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry 47:5565–5572 (2008).
Ramamoorthy, A., Lee, D-K., Santos, J.S. and Henzler-Wildman, K.A. Nitrogen-14 Solid-state NMR spectroscopy of aligned phospholipid bilayers to probe peptide-lipid interaction and oligomerization of membrane associated peptides. J. Am. Chem. Soc. 130:11023–11029 (2008).

James W. Janetka

Zabludoff, S.D., Deng C., Grondine, M.R., Sheehy, A.M., Ashwell, S., Cale, B.L., Green, S., Haye, H.R., Horn, C.L., Janetka, J.W., Liu, D., Mouchet, E., Ready, S., Rosenthal, J.L., Queva, C., Schwartz, G.K., Taylor, K.J., Tse, A.N., Walker, G.E., and White, A.M. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Molecular Cancer Therapeutics 7:2955-2966 (2008).
Ashwell, S., Janetka, J.W. and Zabludoff, S. Keeping checkpoint kinases in line: New selective inhibitors in clinical trials. Expert Opin Investig Drugs 17:1331-1340 (2008).
Janetka, J.W., Almeida, L., Ashwella, S., Brassil, P.J., Daly, K., Deng C., Gero, T., Glynn, R.E., Horn, C.L., Ioannidis, S., Lyne, P., Newcombe, N.J., Oza, V.B., Pass, M., Springer, S.K., Su, M., Toader, D., Vasbinder, M.M., Yu, D., Yu, Y. and Zabludoff, S.D. Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 18:4242-4248 (2008).

Timothy M. Lohman

Shereda, R.D., Kozlov, A.G., Lohman, T.M., Cox, M.M. and Keck, J.L. SSB as an organizer/mobilizer of genome maintenance complexes. CRC Critical Reviews in Biochemistry and Molecular Biology 43:289-318 (2008).
Wu, C.G. and Lohman, T.M. Influence of DNA end structure on the mechanism of initiation of DNA unwinding by the Escherichia coli RedBCD and RecBC helicases. J Mol Biol 382:312-326 (2008).
Lohman, T.M., Tomko, E.J. and Wu, C.G. Non-hexameric DNA helicases and translocases: Mechanisms and regulation. Nat Rev Mol Cell Biol. 9:391-401 (2008).
Wong, C.J. and Lohman, T.M. Kinetic control of Mg(2+)-dependent melting of duplex DNA ends by Escherichia coli RecBC. J Mol Biol. 378:759-775 (2008).

Garland R. Marshall

Taylor, C.M., Barda, Y., Kisselev, O.G. and Marshall, G.R. Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem 51:5297-5303 (2008).
Nikiforovich, G.V., Marshall, G.R. and Baranski, T.J. Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor. Biochemistry 47:3117-3130 (2008).
Cegelski, L, Marshall, G.R., Eldridge, G.R. and Hultgren, S.J. The biology and future prospects of antivirulence therapies. Nature Rev Microbiol. 6:17-27 (2008).
Che, Y. and Marshall, G.R. Privileged scaffolds targeting reverse-turn and helix recognition. Expert Opin Ther Targets 12:101-114 (2008).
Ye, Y., Liu, M., Kao, J.L. and Marshall, G.R. Design, synthesis, and metal binding of novel pseudo-oligopeptides containing two phosphinic acid groups. Biopolymers 89:72-85 (2008).
Berg-Cross, S., Kao, J., Wu, Y. and Marshall, G.R. c[D-pro-Pro-D-pro-N-Methyl-Ala] Adopts a rigid conformation that serves as a scaffold to mimic reverse-turn. Biopolymers 90:384-393 (2008).
Marshall, G.R., Feng, J.A. and Kuster, D.J. Back to the future: Ribonuclease A. Biopolymers 90:259-277 (2008).

F. Scott Mathews

Hassan-Abadallah, A., Zhao, G., Chen, Z., Mathews, F.S. and Schuman Jorns, M. Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: A context-sensitive model for the electrostatic impact of arginine to lysine mutations. Biochemistry 47:2913-2922 (2008).
Gandhi, P.S., Chen, Z., Mathews, F.S. and Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 105:1832-1837 (2008).

Linda J. Pike

Eiblmaier, M., Meyer, L.A., Watson, M.A., Fracasso, P.M., Pike, L.J. and Anderson, C.J. Correlating EGFR expression with receptor-binding properties and internalization of 64Cu-DOTA-Cetuximab in 5 cervical cancer cell lines. J Nucl Med 49:1472-1479 (2008).
Macdonald, J.L. and Pike, L.J. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. PNAS 105:112-117 (2008).

Scott A. Wildman

Sciabola, S., Stanton, R.V., Wittkopp, S., Wildman, S.A., Moshinsky, D., Potluri, S. and Xi, H. Predicting kinase selectivity profiles using free-Wilson QSAR analysis. J. Chem. Inf. Model 48:1851-1867 (2008).

PUBLICATIONS

2009 | 2008 | 2007 | 2006 | 2005 | 2004

The following is a partial list of publications by faculty, post-doctoral fellows, students, and staff of Molecular Biophysics and Biochemistry arranged by labs.

Dong, F., Wagoner, J.A. and Baker, N.A. Assessing the performance of implicit solvation models at a nucleic acid surface. Phys. Chem. Chem. Phys. 10:4889-4902, (2008).

Bradley, M.J., Chivers, P.T. and Baker, N.A. Molecular dynamics simulation of the Escherichia coli NikR protein: Equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. J Mol Biol. 378:1155-1173 (2008).

Lee, S.J., Song, Y. and Baker, N.A. Molecular dynamics simulations of asymmetric NaCl and KCl solutions separated by phosphatidylcholine bilayers: Potential drops and structural changes induced by strong Na+-lipid interactions and finite size effects. Biophys J. 94:3565-3576 (2008).

Dong, F., Olsen, B. and Baker, N.A. Computational methods for biomolecular electrostatics. Methods Cell Biol. 84:843-870 (2008).

Stith, C.M., Sterling, J., Resnick, M.A., Gordenin, D.A. and Burgers, P.M. Flexibility of eukaryotic okazaki fragment maturation through regulated strand sisplacement synthesis. J Biol Chem. 283:34129-40 (2008).

Navadgi-Patil, V.M. and Burgers, P.M. Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem 283:35853-35859 (2008).

Kunkel, T.A. and Burgers, P.M. Dividing the workload at a eukaryotic replication fork. Trends Cell Biol 18:521-527 (2008).

Rossi, M.L., Pike, J.E., Wang, W., Burgers, P.M., Campbell, J.L. and Bambara, R.A. Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem 283:27483-27493 (2008).

Sommer, D., Stith, C.M., Burgers, P.M.J. and Lahue, R.S. Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae. Nuc Acid Res 6:4699-4707 (2008).

Nick McElhinny, S.A., Gordenin, D.A., Stith, C.M., Burgers, P.M. and Kunkel, T.A. Division of labor at the eukaryotic replication fork. Mol Cell. 30:137-144 (2008).

Iwig, J.S., Leitch, S., Herbst, R.W., Maroney, M.J. and Chivers, P.T. Ni(II) and Co(II) sensing by Escherichia coli RcnR. J Am Chem Soc. 130:7592-7606 (2008).

Bradley, M.J., Chivers, P.T. and Baker, N.A. Molecular dynamics simulation of the Escherichia coli NikR protein: Equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. J Mol Biol. 378:1155-1173 (2008).

Papaconstantinou, M.E., Gandhi, P.S., Chen, Z., Bah, A. and Di Cera, E. Na(+) Binding to meizothrombin desF1. Cell Mol Life Sci. 65:3688-3697 (2008).

Page, M.J. and Di Cera, E. Evolution of peptidase diversity. J Biol Chem 283:30010-30014 (2008).

Di Cera, E. How I became a biochemist. IUBMB Life 60:859-861 (2008).

Tanaka, K.A., Gruber, A., Szlam, F., Bush, L.A., Hanson, S.R. and Di Cera, E. Interaction between thrombin mutant W215A/E217A and direct thrombin I\inhibitor. Blood Coagul Fibrinolysis 19:465-468 (2008).

Papaconstantinou, M.E., Bah, A. and Di Cera, E. Role of the A chain in thrombin function. Cell Mol Life Sci. 65:1943-1947 (2008)

Di Cera, E. Engineering protease specificity made simple, but not simpler. Nat Chem Biol 4:270-271 (2008).

Page, M.J., Carrell, C.J. and Di Cera, E. Engineering protein allostery: 1.05 A resolution structure and enzymatic properties of a Na(+)-activated trypsin. J Mol Biol. 378:666-672. (2008).

Di Cera, E. Thrombin. Mol Aspects Med. 29:203-254 (2008).

Page, M.J. and Di Cera, E. Serine peptidases: Classification, structure and function. Cell Mol Life Sci. 65:1220-1236 (2008).

Gandhi, P.S., Chen, Z., Mathews, F.S. and Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 105:1832-1837 (2008).

Berny, M.A., White, T.C., Tucker, E.I., Bush-Pelc, L.A., Di Cera, E., Gruber, A. and McCarty, O.J. Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol. 28:329-334 (2008).

Raschle, M., Knipsheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D. and Walter, J.C. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134:969-980. (2008).

Zhong, S., Chen, X., Zhu, X., Dziegielewska, B., Bachman, K.E., Ellenberger, T., Ballin, J.D., Wilson, G.M., Tomkinson, A.E. and MacKerell, Jr., A.D. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem 51:4553-4562 (2008).

Ellenberger, T. and Tomkinson, A.E. Eukaryotic DNA ligases: Structural and functional insights. Annu Rev Biochem 77:313-338 (2008).

Chen, X., Zhong, S., Zhu, X., Dziegielewska, B., Ellenberger, T., Wilson, G.M., MacKerell, A.D. Jr and Tomkinson, A.E. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68:3169-3177 (2008).

Cotner-Gohara, E., Kim, I.K., Tomkinson, A.E. and Ellenberger, T. Two DNA binding and nick recognition modules in human DNA ligase III. J. Biol. Chem. 283:10764-10772 (2008).

Nekouzadeh, A., Pryse, K.M., Elson, E.L. and Genin, G.M. Stretch-activated force shedding, force recovery, and cytoskeletal remodeling in contractile fibroblasts. J Biomech. 41:2964-2971 (2008).

Tan, Y.C., Shen, A.Q., Li, Y., Elson, E. and Ma, L. Engineering lipid tubules using nano-sized building blocks: The combinatorial self-assembly of vesicles. Lab on a Chip 8:339-345 (2008).

Isenberg, J.S. Maxhimer, J.B., Powers, P., Tsokos, M., Frazier, W.A. and Robert, D.D. Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling. Surgery 144:752-761 (2008).

Isenberg, J.S., Frazier, W.A., Krishna, M.C., Wink, D.A. and Roberts, D.D. Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. Curr Drug Targets 9:833-841 (2008).

Vomund, A.N., Stuhlsatz-Krouper, S., Dimitry, J., Song, Y. and Frazier, W.A. A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 Integrins in a bent, resting conformation. Biochemistry 47:11616-11624 (2008).

Isenberg, J.S., Romeo, M.J., Maxhimer, J.B., Smedley, J., Frazier, W.A. and Roberts, D.D. Gene silencing of CD47 and antibody ligation of Thrombospondin-1 enhance ischemic tissue survival in a porcine model: Implications for human disease. Ann Surg. 247:860-868 (2008).

Isenberg, J.S., Romeo, M.J, Yu, C., Yu, C.K., Nghiem, K., Monsale, J., Rick, M.E., Wink, D.A., Frazier, W.A. and Roberts, D.D. Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood 111:613-623 (2008).

Isenberg, J.S., Roberts, D.D. and Frazier, W.A. CD47. A new target in cardiovascular therapy. Arterioscler Thromb Vasc Biol. 28:615-621 (2008).

Isenberg, J.S., Pappan, L.K., Romeo, M.J., Abu-Asab, M., Tsokos, M., Wink, D.A., Frazier, W.A. and Roberts, D.D. Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. Ann Surg. 247:180-190 (2008).

Frieden, C. A lifetime of kinetics. J Biol Chem. 283:19873-19878 (2008).

Hall, K.B. RNA in motion. Curr Opin Chem Biol 12:612-618 (2008).

Porcelli, F., Verardi, R., Shi, L., Henzler-Wildman, K.A., Ramamoorthy, A., and Veglia, G. NMR Structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry 47:5565–5572 (2008).

Ramamoorthy, A., Lee, D-K., Santos, J.S. and Henzler-Wildman, K.A. Nitrogen-14 Solid-state NMR spectroscopy of aligned phospholipid bilayers to probe peptide-lipid interaction and oligomerization of membrane associated peptides. J. Am. Chem. Soc. 130:11023–11029 (2008).

Ashwell, S., Janetka, J.W. and Zabludoff, S. Keeping checkpoint kinases in line: New selective inhibitors in clinical trials. Expert Opin Investig Drugs 17:1331-1340 (2008).

Shereda, R.D., Kozlov, A.G., Lohman, T.M., Cox, M.M. and Keck, J.L. SSB as an organizer/mobilizer of genome maintenance complexes. CRC Critical Reviews in Biochemistry and Molecular Biology 43:289-318 (2008).

Wu, C.G. and Lohman, T.M. Influence of DNA end structure on the mechanism of initiation of DNA unwinding by the Escherichia coli RedBCD and RecBC helicases. J Mol Biol 382:312-326 (2008).

Lohman, T.M., Tomko, E.J. and Wu, C.G. Non-hexameric DNA helicases and translocases: Mechanisms and regulation. Nat Rev Mol Cell Biol. 9:391-401 (2008).

Wong, C.J. and Lohman, T.M. Kinetic control of Mg(2+)-dependent melting of duplex DNA ends by Escherichia coli RecBC. J Mol Biol. 378:759-775 (2008).

Taylor, C.M., Barda, Y., Kisselev, O.G. and Marshall, G.R. Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem 51:5297-5303 (2008).

Nikiforovich, G.V., Marshall, G.R. and Baranski, T.J. Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor. Biochemistry 47:3117-3130 (2008).

Cegelski, L, Marshall, G.R., Eldridge, G.R. and Hultgren, S.J. The biology and future prospects of antivirulence therapies. Nature Rev Microbiol. 6:17-27 (2008).

Che, Y. and Marshall, G.R. Privileged scaffolds targeting reverse-turn and helix recognition. Expert Opin Ther Targets 12:101-114 (2008).

Ye, Y., Liu, M., Kao, J.L. and Marshall, G.R. Design, synthesis, and metal binding of novel pseudo-oligopeptides containing two phosphinic acid groups. Biopolymers 89:72-85 (2008).

Berg-Cross, S., Kao, J., Wu, Y. and Marshall, G.R. c[D-pro-Pro-D-pro-N-Methyl-Ala] Adopts a rigid conformation that serves as a scaffold to mimic reverse-turn. Biopolymers 90:384-393 (2008).

Marshall, G.R., Feng, J.A. and Kuster, D.J. Back to the future: Ribonuclease A. Biopolymers 90:259-277 (2008).

Gandhi, P.S., Chen, Z., Mathews, F.S. and Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 105:1832-1837 (2008).

Eiblmaier, M., Meyer, L.A., Watson, M.A., Fracasso, P.M., Pike, L.J. and Anderson, C.J. Correlating EGFR expression with receptor-binding properties and internalization of 64Cu-DOTA-Cetuximab in 5 cervical cancer cell lines. J Nucl Med 49:1472-1479 (2008).

Macdonald, J.L. and Pike, L.J. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. PNAS 105:112-117 (2008).

Sciabola, S., Stanton, R.V., Wittkopp, S., Wildman, S.A., Moshinsky, D., Potluri, S. and Xi, H. Predicting kinase selectivity profiles using free-Wilson QSAR analysis. J. Chem. Inf. Model 48:1851-1867 (2008).